@gnasralla : Hi, and thanks for the kind words!
As for your suggestion, it's a general sort of thing that's definitely possible. Emails have headers that contain some info about how the email can be handled by mail clients. One such header is "Reply-To" which indicates (for most mail clients) who to reply to, which can be separate from who sent the email.
The only issue for that with regards to this plugin is that this plugin sets up the mail handler used generally by WordPress and itself does not handle specific emails. To do so would start to get into doing things a little afield of its purpose.
However! It's a good idea that can be done in a separate, dedicated plugin that would be compatible with a site whether it is using Configure SMTP or not. I'm going to give it some consideration. I can't make any promises or theorize a timetable, but I'll let you know if I do so.